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In addition, NO reacts with superoxide (O 2 ), a major ROS, to produce peroxynitrite (ONOO), a potent oxidant that damages cellular components such as proteins, lipids, and DNA [136138]

Human results are not established, and large human trials have not been completed, which is a critical limit to keep in mind

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This leads to a reduction in the quality of oocytes, particularly resulting in reduced metabolic activity, which may affect cell cycle regulation, spindle formation during mitosis, chromosome segregation, fertilisation, embryo development, and implantation [79]

Effect of epigallocatechin-3-gallate on the status of DNA methylation of E-cadherin promoter region on endometriosis mouse